Differin cream and gel topical, containing retinoid (adapalene 0.1%) applied once daily to treat acne as part of a treatment plan.

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How to buy online

  1. Read medical information about acne treatment
  2. Answer medical questions to check for eligibility
  3. Reviewed by doctors - posted from UK pharmacy


Acne treatmentQuantityCost
Differin cream (adapalene 0.1%)45 grams£22.00
Differin cream (adapalene 0.1%)90 grams (2 x 45 grams)£39.00
Differin gel (adapalene 0.1%)45 grams£22.00
Differin gel (adapalene 0.1%)90 grams (2 x 45 grams)£39.00

Dr Fox charges a small prescription fee per order.

Prescription fees

Dr Fox supplies medicine on prescription and charges a small prescription fee based on the order value of each prescription.

Prescriptions are issued by our doctors online and sent electronically to our pharmacy.

If you have your own private paper prescription please post to our pharmacy (details).

Dr Fox prices are 25%–50% lower than other UK online clinics.

Order valuePrescription fee
up to £10£1.00
up to £20£3.00
up to £50£5.00
up to £100£8.00
over £100£10.00

Delivery charges

UK delivery only: £2.90 per consultation via Royal Mail 24 Signed For (1-3 working days with tracking).

Parcel forwarding services are not permitted. Use only UK home or work delivery address.

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About Differin


Differin is a once daily topical treatment for acne. The active ingredient, adapalene, reduces spots and inflammation. Adapalene is a type of medicine known as a retinoid and is supplied in the UK by the pharmaceutical company Galderma.

Differin should be applied to acne prone areas, usually in the evenings, to areas of the face, back and chest affected by spots and inflammation, particularly where blackheads and whiteheads are present.

Whats a good treatment plan?

Treatment with Differin should be continued for at least 8 weeks. If after that time there is no improvement, treatment should be stopped or new types of treatment should be added.

After 3 months, treatment should be reviewed, and if acne has cleared Differin can be stopped. Acne may not come back, and if it does treatment can be restarted. Both Differin and over the counter benzoyl peroxide can be used long term (for many months or years) if needed.

With other acne treatments

Differin can be used with topical preparations containing clindamycin (Duac) or erythromycin (Zineryt) or benzoyl peroxide (non-prescription medicine). When other topical medicines are used with Differin these are usually applied at different times of the day.

Differin should not be used at the same time with other topical retinoids.

Side effects of Differin – cautions

Localised side effects, notably soreness, redness and inflammation of the skin are common, particularly early in treatment. Treatment frequency should be reduced if this occurs, or stopped if there is marked inflammation.

Generalised side effects are unlikely, as little of the active ingredients are absorbed through the skin.

Using Differin more frequently than daily will not increase effectiveness, but will increase the chances of side effects.

Sensitivity to UV light is increased and sun avoidance measures, including the use of sunscreens, are recommended.

Differin is for topical use only. Avoid contact with mouth and eyes. If accidentally ingested contact a doctor straight away.

Pregnancy and breastfeeding

Avoid use in pregnancy. Differin can be used by breastfeeding women, although application to the chest area should be avoided.

Patient information leaflets

The 'Patient Information Leaflet' supplied with treatment must be read before use.

Differin Gel Patient Information Leaflet
Differin Cream Patient Information Leaflet

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Authored 19 November 2015
by Dr Tony Steele, MB ChB

Reviewed 15 January 2018 by Dr B. Babor, Dr A. Wood, Dr P. Hunt

Last updated 3 March 2018

The order process

Answer short medical questionnaire

Choose treatment, register, and pay

Doctor issues prescription online

Medicine posted direct from pharmacy

Customer reviews

“Fast service with good prices. UK pharmacy which is professional and you can always be confident”15 March 2018 – Michael M., London

“Just used Dr Fox for the first time. Brilliant service. Will definitely use them again for my required medication.”23 February 2018 – Steve B., Devon

“Efficient and timely. The product was effective and I would recommend”18 February 2018 – Anonymous

“Entirely hassle free transaction. I would not hesitate to recommend using Dr Fox. Indeed, I already have made a recommendation to one of my work colleagues. So simple to arrange my meds and they get delivered to my door. Perfect”07 February 2018 – Jay R., Northampton

“Everything done very professionally and efficiently from the initial consultation process to delivery”04 February 2018 – Alan J., Leicester

“Such a trustworthy on line store. It was recommended to me and I have recommended it to others, with no hesitation. Choice is good, prices excellent and I know my delivery will arrive within a day or 2. Thank you Dr Fox”25 January 2018 – Helen H., Notts

“Very quick response from the doctors and delivery. Only 3 days from order to delivery. You can't find that type of service when ordering from abroad .only in the UK you can”22 January 2018 – Antony Glen H., Brighton

“Very good service and quick delivery. Quicker than booking an appointment and waiting for ages for the prescribed medication. Thank you very much for your help and assistance.”16 January 2018 – Nigel G., Surrey

“Excellent products. Service is always good and delivery was very prompt even over the busy Xmas period.”11 January 2018 – Paul S., Southsea

“First class service, fast delivery, I have recommended DR Fox to my friends Thank you for excellence, I would highly recommended this site.”04 January 2018 – Richard B., London

“First time I had used Dr Fox but so simple and easy process and was kept informed regarding order and arrived promptly. I would definitely use again and recommend to others.”01 January 2018 – Max L., Uxbridge

“I would recommend this site its easy cheaper than the rest and delivered really fast”26 December 2017 – Andrew E., Sheffield

“A superb service and Dr Fox does not charge the disgustingly high prices of other online pharmacies.”18 December 2017 – David L., Wellington

“Order was confirmed and dispatched without issue. Arrived in 1 day well packaged and discrete if this is an issue to you. Will be using again as they are best prices online”14 December 2017 – Andy U., Plymouth

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