Differin cream and gel

Differin cream and gel topical, containing retinoid (adapalene 0.1%) used to treat acne as part of a treatment plan.

  • Once daily topical treatment for acne
  • Available as a cream or gel
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How to buy Differin cream and gel online

Differin is prescription only medicine.

To buy Differin online patients (over 18 years) will need to complete an online consultation for acne treatment before making an order.

  1. Read important medical information about acne treatment
  2. Answer medical questions to check for eligibility

Once completed patients choose treatment, register details, and pay online. A doctor will review your order and issue the prescription electronically to our pharmacy. Medicine is then delivered direct to you.


Acne treatmentQuantityCost
Differin cream (adapalene 0.1%)45 grams£22.00
Differin cream (adapalene 0.1%)90 grams (2 x 45 grams)£39.00
Differin gel (adapalene 0.1%)45 grams£22.00
Differin gel (adapalene 0.1%)90 grams (2 x 45 grams)£39.00
Start order

Dr Fox charges a small prescription fee per order.

If you have your own private paper prescription please post to our pharmacy (details).

Differin is prescription only medicine. You are required to answer medical questions before completing an order. A doctor will review your information and issue a prescription online to our pharmacy.

Prescription fees

Dr Fox supplies medicine on prescription and charges a small prescription fee based on the order value of each prescription.

Prescriptions are issued by our doctors online and sent electronically to our pharmacy.

If you have your own private paper prescription please post to our pharmacy (details).

Dr Fox prices are 25%–50% lower than other UK online clinics.

Order valuePrescription fee
up to £10£1.00
up to £20£3.00
up to £50£5.00
up to £100£8.00
over £100£10.00

Differin cream and gel product information


Differin is a once daily topical treatment for acne. The active ingredient, adapalene, reduces spots and inflammation. Adapalene is a type of medicine known as a retinoid and is supplied in the UK by the pharmaceutical company Galderma.

Differin should be applied, usually in the evenings, to areas of the face, back and chest affected by spots and inflammation, particularly where blackheads and whiteheads are present.

Whats a good treatment plan?

Treatment with Differin should be continued for at least 8 weeks. If after that time there is no improvement, treatment should be stopped or new types of treatment should be added.

After 3 months, treatment should be reviewed, and if acne has cleared Differin can be stopped. Acne may not come back, and if it does treatment can be restarted.

With other acne treatments

Differin can be used with topical preparations containing clindamycin (Dalacin T and Duac) or erythromycin (Zineryt) or benzoyl peroxide (non-prescription medicine). When other topical medicines are used with Differin these are usually applied in the morning and Differin in the evening.

Differin should not be used at the same time with other topical retinoids, e.g. Isotrex.

Side effects of Differin – cautions

Localised side effects, notably soreness, redness and inflammation of the skin are common, particularly early in treatment. Treatment frequency should be reduced if this occurs, or stopped if there is marked inflammation.

Generalised side effects are unlikely, as little of the active ingredients are absorbed through the skin.

Using Differin more frequently than daily will not increase effectiveness, but will increase the chances of side effects.

Sensitivity to UV light is increased and sun avoidance measures, including the use of sun screens, are recommended.

Differin is for topical use only. Avoid contact with mouth and eyes. If accidentally ingested contact a doctor straight away.

Pregnancy and breast-feeding

Avoid use in pregnancy. Differin can be used by breast feeding-women, although application to the chest area should be avoided.

Alternative treatments

Alternatives topical retinoids (Isotrex) and other acne treatments are available from Dr Fox.

Patient information leaflets – Differin

The 'Patient Information Leaflet' supplied with treatment must be read before use.

Differin Gel Patient Information Leaflet
Differin Cream Patient Information Leaflet

Start order

The order process

Answer short medical questionnaire

Choose treatment, register, and pay

Doctor issues prescription online

Medicine posted direct from pharmacy

Independent reviews

“I'm completely satisfied with the whole process from start to finish. Great prices, superb communication and rapid delivery....highly recommended”08 October 2016 – Davey W., London

“I've used Dr Fox a couple of times now for malaria tablets. On both occasions I received a fast and reliable service. The prices are very good too. No need to pay your GP for a private prescription or pay High Street Chemist prices. Highly recommended.”04 October 2016 – Pete M., Corsham

“My experience is of top customer service with fast deliveries of genuine products sold at the lowest price around. I haven't dealt with better and believe they are unmatched so unrivalled.”02 October 2016 – Jason J., Colchester

“Great service quick uncomplicated good price”20 September 2016 – Mike H., Newcastle upon Tyne

“Answered questionnaire, ordered product. Product is competitively priced and delivered speedily - absolutely no criticism of any kind from me - product works every time.”08 September 2016 – Lionel E., Wigan

“I have used Dr Fox three times now and I find the service easy to use, with good products and delivery usually by return. I also feel confident about using the site and believe that they would only market products that were of reputable origin and safe to use.”22 August 2016 – Robin S., London

“very cautious about buying medicines online but Dr Fox seemed a credible retailer with a good reputation. Thankfully that turned about to be true. Ordering is relatively quick (even quicker to do a repeat order) and simple. The service has been good and I've had no reason to contact them even after many orders.”21 August 2016 – Andy B., Reading

“Impressively fast service to Malta. Also very helpful when I needed to ask a question. Very highly recommended.”17 August 2016 – Anonymous

“As this was the first time i had bought online, i was wary. So i checked the batch number with the manufacturer to make sure my medicine was legitimate and it was. I will definitely use again.”17 April 2016 – Anonymous

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