Colofac (mebeverine) to relax bowel spasms in IBS. Treats abdominal pain, cramps, wind and diarrhoea. Colofac tablets and capsules for IBS relief available to buy online from Dr Fox.

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Buy Colofac online in UK

How to order Colofac online for UK delivery:

  1. Read medical information about irritable bowel syndrome
  2. Answer medical questions to check for eligibility
  3. Reviewed by doctors - posted from UK pharmacy (tracked 24hr service)


Medication Quantity Cost
Colofac (mebeverine 135mg) 100 sugar-coated tablets £12.10
Colofac (mebeverine 135mg) 200 sugar-coated tablets £21.40
Colofac MR (mebeverine 200mg) 60 slow release capsules £11.30
Colofac MR (mebeverine 200mg) 120 slow release capsules £18.10

Price match guarantee
Prescription issued online - small prescription fee per order.

Prescription fees

Dr Fox supplies medicine on prescription and charges a small prescription fee based on the order value of each prescription.

Prescriptions are issued by our doctors online and sent electronically to our pharmacy.

Order value Prescription fee
up to £10 £1.00
up to £20 £2.00
up to £40 £3.00
over £40 £4.00

If you have your own private paper prescription please post to our pharmacy (details).

Dr Fox prices are 25%–50% lower than other UK online clinics.

Delivery charges

UK delivery only: £2.90 per consultation via Royal Mail Tracked 24 Signed For (1-3 working days with tracking).

Parcel forwarding services are not permitted. Use only UK home or work delivery address.

Returns and refunds - unwanted items can be returned within 14 working days for a full refund.

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About Colofac

  • Colofac (mebeverine) tablets and capsules are used to treat Irritable Bowel Syndrome (IBS).
  • Relieves abdominal pain, excessive wind, and diarrhoea.
  • Available in 135mg tablets (3 times daily) and 200mg capsules (twice daily).
  • Read the patient leaflet for a full list of side effects, cautions, and interactions with other drugs.

How does Colofac work?

Colofac contains the active ingredient mebeverine, an anticholinergic medicine, that directly relaxes bowel spasm, whilst allowing the bowel to continue to work effectively. Mebeverine is effective at treating colicky abdominal pain and cramps, excessive wind (flatulence), and can help with loose stools/diarrhoea.

Mebeverine is also available as a drink combination with ispaghula husk (Fybogel).

Can anyone take Colofac?

Most people with IBS are able to take Colofac.

It is important to be sure that your symptoms are caused by IBS and not something more serious.

If any of the following apply, check with your GP before using Colofac:

  • Changed or new symptoms especially in women.
  • Over 40 years old with first symptoms.
  • New symptoms of blood in your stool or motions.
  • Feeling nauseous or loss of appetite.
  • Losing weight without dieting.
  • Pale and tired.
  • Severely constipated.
  • Running a high temperature (fever).
  • Travelled abroad recently.
  • Are or may be pregnant.
  • Urinary symptoms as well.

Colofac is licensed for use in adults only and is not recommended for use in children.

Taking Colofac with other medicines

Colofac is suitable to take with most other medications, but do not take at the same time as other antispasmodics, e.g. Spasmonal (alverine) or Buscopan (hyoscine).

Can Colofac be used in pregnancy and whilst breastfeeding?

In general, all medication should be avoided whilst trying for pregnancy, and when pregnant or breastfeeding.

There are no studies about the safety of Colofac during pregnancy or whilst breastfeeding so it should not be used.

Side effects of Colofac

Most people experience no side effects at all from Colofac.

However as with any medication there is a risk of allergy ranging from mild skin reactions to the more severe anaphylaxis. Severe allergic reactions to Colofac are extremely rare. If you have reacted to an antispasmodic medication in the past, do not try a different antispasmodic as the reaction is likely to be the same.

Further information on side effects can be found in the manufacturer's patient information leaflets.

How to take Colofac

Colofac 135mg tablets

Take one Colofac 135mg sugar-coated tablet 3 times a day about 20 minutes before meals as gut spasms are usually strongest after eating. Symptoms should improve within 2 hours.

Colofac MR 200mg capsules

Colofac MR 200mg are slow release capsules which are taken twice daily in the morning and evening, providing a more constant treatment. Swallow one capsule whole with a glass of water. Do not chew as this destroys the slow release mechanism.

Other measures to help symptoms of IBS

Diarrhoea and bloating - reduce insoluble fibre like bran, wholegrain bread, and brown rice. Reduce caffeine, alcohol, fizzy drinks, and gas-producing foods like beans and cabbage.

Constipation - try adding more soluble fibre like oats and linseed, or soluble fibre supplements like Fybogel (ispaghula). Increase the soluble fibre gradually or bloating and wind may get worse. It may take several weeks for optimal benefits.

Regular physical activity is also helpful for the bowels. Aim for 30 minutes of moderate activity at least 5 days per week.

It is also important to drink plenty of fluids (at least 8 cups per day) when constipated, especially if taking Fybogel.

Further information

Patient Information Leaflet

Illustration of patient leaflet from medicine packet

The Patient Information Leaflet (PIL) is the leaflet included in the pack with a medicine and must be read before taking the medicine. It is written for patients and gives information about taking or using a medicine.

Colofac 135mg patient leaflet
Colofac 200mg patient leaflet

Dr Amanda Wood

Authored 28 January 2022 by Dr Amanda Wood
MB ChB Manchester University 1984. Former NHS GP in Bristol. GMC no. 2855422

Reviewed by Dr C. Pugh, Dr B. Babor
Last reviewed 28 January 2022
Last updated 19 July 2024


Recent Colofac reviews

Colofac rated 4.91/5 in 23 product reviews

See over 40,000 service reviews of Dr Fox

Colofac capsules m/r (mebeverine 200mg)

A great high quality mebeverine.

18 April 2024
Anonymous Verified

Colofac capsules m/r (mebeverine 200mg)

Works well for me.

11 May 2023
N. Barber Verified

Colofac capsules m/r (mebeverine 200mg)

These are the only thing that works. Brilliant service from Dr.Fox. no hesitation in recommending.

26 April 2023
Anonymous Verified

Colofac capsules m/r (mebeverine 200mg)

Wish i had used earlier work well very effective for ibs

27 February 2023
R. May Verified

Colofac capsules m/r (mebeverine 200mg)

Great service as ever

13 September 2022
B. Coogan Verified

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The order process

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