Medicines linked to ED

Side effects of your regular medication may contribute to erectile dysfunction - check with your GP.

Regular tablets may be the cause

If you take medicine from the list below you should consult with your regular doctor before you start erectile dysfunction treatment. Adjusting your regular medication may help with erectile dysfunction. You should not stop medication before talking to your regular doctor.

Erectile dysfunction treatments are usually still effective even if medications from the list below are being taken at the same time.

Prescribed MedicinesMain usePossible effect on sexual function
PhenelzineDepressionDecreased sex drive, impotence, delayed orgasm, ejaculatory disturbances
SSRI antidepressants (e.g. fluoxetine, sertraline, citalopram)DepressionDecreased sex drive, impotence, delayed or absent orgasm, ejaculatory disturbances
Tricyclic antidepressants (e.g. amitryptiline)DepressionDecreased sex drive, impotence, delayed or absent orgasm, ejaculatory disturbances
LithiumDepression, bipolarImpotence
ACE inhibitors (e.g. ramipril, enalapril, lisinopril)High blood pressure, heart failureImpotence
Alpha-blockers (e.g. prazosin, doxazosin)High blood pressure, enlarged prostateImpotence, ejaculatory disturbances
Beta-blockers (e.g. atenolol, propranolol and including timolol eye drops)High blood pressure, angina, glaucomaImpotence
Calcium channel blockers (e.g. verapamil, nifedipine)High blood pressure, anginaImpotence
ClonidineHigh blood pressureImpotence, decreased sex drive, delayed or failure of ejaculation
MethyldopaHigh blood pressureImpotence, decreased sex drive, ejaculatory failure
Thiazide diuretics (e.g. bendroflumethiazide)High blood pressureImpotence
Phenothiazines (e.g. chlorpromazine, thioridazine)Psychotic illnessEjaculatory disturbances, decreased sex drive, impotence
RisperidonePsychotic illnessImpotence, ejaculatory disturbances
Cholesterol lowering medicines
Fibrates (e.g. clofibrate, gemfibrozil)High cholesterolImpotence
Statins (e.g. simvastatin)High cholesterolImpotence
BenzodiazepinesAnxiety and insomniaDecreased sex drive
CimetidinePeptic ulcers, acid reflux diseaseDecreased sex drive, impotence
Cyproterone acetateProstate cancerDecreased libido, impotence, reduced volume of ejaculation
DisulfiramAlcohol withdrawalDecreased sex drive
FinasterideEnlarged prostateImpotence, decreased sex drive, ejaculation disorders, reduced volume of ejaculation
MetoclopramideNausea and vomitingDecreased sex drive, impotence
Opioid painkillers (e.g. codeine, morphine)Severe painDecreased sex drive, impotence
ProchlorperazineNausea and vomitingImpotence
SpironolactoneHeart failure, fluid retentionImpotence, decreased sex drive
Buy ED treatment
Dr Tony Steele

Authored 12 July 2010 by Dr Tony Steele
MB ChB Sheffield University 1983. Former hospital doctor and GP. GMC no. 2825328

Reviewed by Dr C. Pugh, Dr B. Babor, Dr A. Wood
Last reviewed 20 July 2021
Last updated 28 November 2023