Acne treatment

Antibiotic or retinoid creams, gels and lotions, plus antibiotic tablets to treat acne. Medicine on prescription from UK pharmacy.

Read medical information and answer medical questions to buy treatment online.

Treatment available

Prices
lymecycline

Lymecycline 408mg (antibiotic)

28-84 capsules from £14.80

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zineryt

Zineryt lotion (erythromycin)

30-90mls from £14.20

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duac gel

Duac (benzoyl peroxide 3% & clindamycin 1%)

30-90gms from £18.50

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differin

Differin cream & gel (adapalene 0.1%)

45-90gms from £22.00

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Epiduo gel

Epiduo gel (benzoyl peroxide 2.5% & adapalene 0.1%)

45-135gms from £26.20

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Prices

Acne treatmentQuantityCost
Zineryt (erythromycin in solution)30mls£14.20
Zineryt (erythromycin in solution)90mls (1 x 90mls)£33.00
Differin cream (adapalene 0.1%)45 grams£22.00
Differin cream (adapalene 0.1%)90 grams (2 x 45 grams)£39.00
Differin gel (adapalene 0.1%)45 grams£22.00
Differin gel (adapalene 0.1%)90 grams (2 x 45 grams)£39.00
Duac gel (benzoyl peroxide 3% and clindamycin 1%)30 grams£18.50
Duac gel (benzoyl peroxide 3% and clindamycin 1%)60 grams (1 x 60 grams)£35.80
Epiduo gel (benzoyl peroxide 2.5% and adapalene 0.1%)45 grams£26.20
Epiduo gel (benzoyl peroxide 2.5% and adapalene 0.1%)90 grams (2 x 45 grams)£46.00
Epiduo gel (benzoyl peroxide 2.5% and adapalene 0.1%)135 grams (3 x 45 grams)£69.00
Lymecycline 408mg28 capsules£14.80
Lymecycline 408mg56 capsules£22.00
Lymecycline 408mg84 capsules£32.00

Prescription issued online - small prescription fee per order.

Compare prices: Dr Fox prices are 25%-50% lower cost than other online clinics.

Prescription fees

Dr Fox supplies medicine on prescription and charges a small prescription fee based on the order value of each prescription.

Prescriptions are issued by our doctors online and sent electronically to our pharmacy.

If you have your own private or NHS paper prescription please post to our pharmacy (details).

Dr Fox prices are 25%–50% lower than other UK online clinics.

Order valuePrescription fee
up to £10£1.00
up to £20£3.00
up to £50£5.00
up to £100£8.00
over £100£10.00
Comparative costs of acne treatments from UK online clinics (7 March 2016) - qualifying notes
*Dr Fox adds a small prescription fee not included in table above.
  1. The prices shown are listed by the online clinics named after a customer first enters consultation information and is offered prescriptions. It is possible these clinics may have special offers or lower prices for repeat supplies.
  2. Prices may change and are, to the best of our knowledge, accurate on the date stated.
  3. Dr Fox does NOT claim to provide a superior service to any of the online clinics listed. All the clinics listed, as far as we can tell, comply with all regulation and, as far as we can tell, operate to high ethical standards.
  4. Dr Fox adds a small prescription fee not included in the table (between £1 and £10 depending on value of the order).
  5. To amend the information in this table please contact us
  6. The prices listed in the table do not identify the cost of prescription medicine as online clinics charge a single fee to cover services which includes advice, consultations, prescriptions and dispensing and supply of treatments.
TreatmentDr Fox*Pharmacy2USuperdrugChemist Direct
Zineryt 30ml£14.20£23.00n/a£22.99
Differin cream 45gm£22.00£35.00n/a£35.00
Epiduo gel 45gm£26.20£35.00£49.00n/a
Lymecycline 408mg x 84£32.00£45.00£45.00n/a
UK delivery£2.90£3.45included£3.49/free

Delivery charges

New advice (December 2016)

We no longer supply Dalacin T. New evidence suggests there is a risk that using this topical antibiotic on its own long-term increases the chances of antibiotic resistance. Duac, which contains the same antibiotic (clindamycin) combined with a mild peeling agent, is an alternative with less chance of antibiotic resistance. Another alternative topical antibiotic is Zineryt (erythromycin) which is also less prone to antibiotic resistance than Dalacin T.

If antibiotic tablets (lymecycline) or topical antibiotics (Zineryt, Duac) are used long-term (more than 4 months), bacteria may possibly build-up resistance, and treatment can become less effective.

Isotrex Gel discontinued April 2017.


Medical information

Acne is common, potentially distressing, and usually treatable.

Many young people have some acne, usually lasting about 4-5 years, although acne is not uncommon in adults and can last longer. The face is the most commonly affected area, although it can also occur on the chest and back and less frequently on the buttocks and in other places.

Acne arises when skin pores become blocked leading to a build-up of secretions (sebum) within the skin. Sometimes in more severe forms, infection, pustules, and cysts may occur. Acne is not the same as rosacea, which sometimes appears similar.

Untreated, acne usually clears up without scarring. Acne can be treated with non-prescription topical preparations (creams, gels and solutions) bought from chemists/pharmacies or alternatively with prescription topical preparations and prescription tablets, including antibiotics. Prescription treatments can be obtained only through doctors, including online doctors.

Acne treatment from Dr Fox

Dr Fox does NOT supply medicines for under-18s.

Dr Fox is able to supply a range of prescription topical preparations (Differin, Zineryt, Duac, and Epiduo) and antibiotic tablets (Lymecycline) for the treatment of acne.

Treatment is usually stepped-up, starting with lower dose single component topical preparations, moving on to dual component (more than one active ingredient) topical preparations. Antibiotic tablets can be taken at the same time whilst using some topical treatments. See Acne treatment plans on this page.

Not all treatments work well in all people. It may be necessary to try different treatments to find the right one.

Some acne treatments are not available online from Dr Fox, particularly isotretinoin tablets and Dianette.

Severe acne with scarring needs to be treated straightaway in face-to-face consultations with GPs or skin specialists.

Zineryt, Differin, Duac, Epiduo, and Lymecycline 408mg are only available on prescription – our doctors will issue the prescription online direct to our pharmacy.

Ordering online

You must read the manufacturer's 'patient information leaflets' (links below) before ordering.

You will need to complete a short Yes/No questionnaire before ordering.

Sometimes different topical preparations contain the same active ingredients. Some topical preparations contain two active ingredients. You should not usually use more than one topical treatment at the same time, without discussing this with a doctor.

  • Zineryt – antibiotic
  • Differin – retinoid
  • Epiduo – retinoid with peeling agent (benzoyl peroxide)
  • Duac – antibiotic with peeling agent (benzoyl peroxide)

Antibiotic tablets (Lymecycline) can be taken whilst using topical Differin, and Epiduo, but should NOT be taken whilst using Zineryt or Duac (topical antibiotics).

Multiple ordering

After the consultation you can choose your order option, although it is not possible to order more than one item per consultation. This is for medical reasons.

If more than one item is required, a separate questionnaire must be completed for each item.

If more than one item has been ordered, you should web-message the doctors from your account to explain why.

If the doctors approve more than one item, email info@doctorfox.co.uk or web-message from your account and we will refund additional postage and consultation fees.

Declined orders are automatically refunded.

Diagnosis of acne

It is important that people obtaining treatment online for acne have previously seen a doctor about it. There are other causes of spots and rashes apart from acne. These other skin problems might require investigations, and might not respond to acne treatment. In some rare cases acne is associated with hormonal disturbance requiring investigation. This is rare. Women with acne and facial hirsutism, and irregular periods should be checked for polycystic ovaries.

Length of treatment

Creams, solutions or gels and antibiotic tablets for acne take time to work, usually at least 8 weeks and sometimes up to 4 months. It is best to use one new treatment at a time, and allow 8 weeks of continuous treatment before switching to, or adding a new one. If a treatment works well, stick with it.

The best response to treatment is usually seen after 4 to 6 months. If acne has completely gone or very much improved after 4 to 6 months, treatment can sometimes be stopped. Treatment may need to restarted if the acne comes back. If acne comes back, maintenance long-term treatment may be needed, possibly with a lower or less frequent amounts being required. If antibiotic tablets (lymecycline) or topical antibiotics (Zineryt, Duac) are used long-term (more than 4 months), bacteria may possibly build-up resistance, and treatment can become less effective.

If there is no improvement or a worsening of acne after 8 weeks, a different treatment can be tried, or a new acne treatment can be added.

If acne is scarring or you are distressed by your skin problems, consult your GP straightaway.

Acne treatment plans

See a doctor face-to-face for diagnosis and advice before you start treatment.

See Acne FAQs. A useful guide to acne and its treatment can also be found at patient.info. There is also a longer more detailed NHS guide to help with treatment options.


Plan one

  1. For mild acne, start with non-prescription benzoyl peroxide topical preparations bought from chemists/pharmacies without prescriptions. Try this for 8 weeks. Topical benzoyl peroxide is not available from Dr Fox.
  2. If step 1 is not working, stop it and try prescription topical treatment, either a topical antibiotic (Zineryt) or topical retinoid (Differin). Try each one in turn for 8 weeks, and if not working, switch to another one for 8 weeks. All available from Dr Fox.
  3. If step 2 is not working, stop it and try a combination topical treatment, either Duac or Epiduo. If one does not work after 8 weeks, switch to the other one for 8 weeks – both available from Dr Fox.
  4. If step 3 does not work, start antibiotic tablets (Lymecycline). Antibiotic tablets (Lymecycline) can be taken on their own, or whilst using Differin and Epiduo, but NOT whilst using Zineryt and Duac (topical antibiotics) - Lymecycline is available from Dr Fox.

Try different treatments on their own first. Only use more than one treatment at a time, if single treatments are not working.

Care should be taken not to use two treatments with the same type of ingredients at the same time, i.e. do not use two topical retinoids at the same time, or two topical antibiotics at the same time.

If acne is well controlled after 4 to 6 months, reduce the frequency of topical applications, or stop using treatment altogether. Acne may not come back, and if it does, treatment can be started again.


Plan two

Same as plan one, except instead of trying the whole range of topical preparations first, add in antibiotic tablets (Lymecycline), at an earlier stage or from the beginning, but do NOT use Zineryt or Duac (topical antibiotics) with antibiotic tablets (Lymecycline) at the same time.


Available treatments for acne

Topical antibiotic for acne: Zineryt & Duac

Acne is associated with infection of the skin which can be reduced by applying creams, lotions or gels which contain antibiotics. Topical antibiotics should NOT be used at the same time as taking antibiotic tablets (Lymecycline).

Topical antibiotics are not normally recommended for more than 4 months at a time because antibiotic resistance could build-up, although Zineryt and Duac are less prone to antibiotic resistance than other topical antibiotics.

Duac is a gel which contains the antibiotic clindamycin combined with an astringent (peeling agent) benzoyl peroxide. See the manufacturer's 'patient information leaflet' of Duac 3% for details, including how to use, side effects, and cautions.
Duac Gel 3% Patient Leaflet

Zineryt contains the antibiotic erythromycin in solution. It is usually applied twice daily. See the manufacturer's patient information leaflet of Zineryt for details, including how to use, side effects, and cautions. Please note: pharmacists are required to pre-mix Zineryt before posting, and once constituted has an 8-week shelf life.
Zineryt Patient Leaflet

Topical retinoid: Differin

Retinoids are good at unplugging blocked pores.

They can cause irritation particularly at the start of treatment. Irritation can be reduced by starting treatment on alternate days, and building up to the prescribed dose as tolerated.

Differin comes as a gel or a cream containing the retinoid, adapalene. It is applied to the skin once daily, usually at night. See the manufacturer's 'patient information leaflet' of Differin Gel and Differin Cream for details, including how to use, side effects and cautions.
Differin Gel Patient Leaflet
Differin Cream Patient Leaflet

Combination topical treatments: Epiduo

Can cause irritation particularly at the start of treatment. Irritation can be reduced by starting treatment on alternate days, and building up to the prescribed dose as tolerated.

Epiduo is a gel containing the retinoid adapalene combined with an astringent (peeling agent) benzoyl peroxide, 2.5%. It is applied once daily. See the manufacturer's 'patient information leaflet' of Epiduo Gel for details, including how to use, side effects and cautions.
Epiduo Gel Patient Leaflet

Antibiotic tablets: Lymecycline 408mg

Lymecycline 408mg is a capsule containing the antibiotic lymecycline of the tetracycline type. The dose used to treat acne is usually one capsule daily. Lymecycline should not normally be taken continuously for more than 6 months because this increases the chances of antibiotic resistance.

NOT to be taken whilst using Zineryt or Duac (topical antibiotics).

See the manufacturer's 'patient information leaflet' of Lymecycline 408mg for details, including how to use, side effects and cautions.
Lymecycline 408mg Patient Leaflet


Antibiotic guardianship

Antibiotic Guardian logo

To combat antibiotic resistance please:

  • Only use antibiotics when needed
  • Never share antibiotics
  • Always complete course as instructed
  • Take unused medicine to local pharmacy for disposal

Buy treatment

Dr Fox supplies acne treatment on prescription – you are required to answer a short medical questionnaire before your order can be completed.


Authored 31 October 2013 by Dr Tony Steele, MB ChB

Reviewed 30 November 2016 by Dr B. Babor, MB ChB

Last updated 16 June 2017


  1. Medical questions
  2. Choose treatment
  3. Complete order

IMPORTANT
It is not possible to order more than one item per consultation. This is for medical reasons.
If more than one item is required, a separate consultation must be completed for each item.
If more than one item has been ordered, you should message the doctors to explain why.
If the doctors approve more than one item on separate consultations, email info@doctorfox.co.uk or send message from your account and we will refund additional postage and consultation fees. Declined items are automatically refunded.
21 Feb 2017: Isotrex currently unavailable - no date for resupply provided by manufacturer.

Answer medical questions to order(acne)

Have you read the acne important information page in full - UPDATED Dec 2016?

If you do not understand the medical information please do NOT order.
If more information is required, discuss with your own GP, or email, phone or message our doctors BEFORE ordering.

Have you seen a doctor face-to-face and been diagnosed with acne?

Have you read the manufacturer’s ‘patient information leaflet’ for the treatment you require?

See links to these leaflets on the medical information section. Read the leaflet(s) BEFORE ordering.

Are you aware you should NOT USE more than one of the SAME TYPE of topical treatments at the SAME TIME?

  • Zineryt - antibiotic
  • Differin - retinoid
  • Epiduo - anti-inflammatory with retinoid
  • Duac - antibiotic with peeling agent (benzoyl peroxide)

Are you aware Lymecycline antibiotic tablets should not be taken whilst using Zineryt or Duac (topical antibiotics)?

Lymecycline can be taken whilst using Differin and Epiduo.

Are you aware it usually takes 8 weeks or more of continuous usage for treatments to work?

If there is no improvement after 4 months, treatment should be stopped or changed.

Are you aware, if acne has cleared-up, treatment can sometimes be stopped or reduced after 4 to 6 months?

Are you aware you should see your GP if acne is scarring or getting worse?

Are you allergic to the treatment you plan to order?

Zineryt (erythromycin), Differin (adapalene), Epiduo (adapalene with benzoyl peroxide), Duac (clindamycin with benzoyl peroxide), Lymecycline (tetracycline).

Are you aware the following treatments should NOT be used if you are pregnant or breast feeding?

  • Differin
  • Epiduo
  • Lymecycline

Details can be found in the ‘patient information leaflets’

Are you aware topical treatments containing retinoids and peeling agents (Differin, Epiduo, and Duac) can be irritant?

Irritation can be reduced by starting treatment on alternate days, and building up to the prescribed dose as tolerated.

Are you ordering Lymecycline and been diagnosed with liver or kidney disease?

Do the following apply to you?

  • I am over 18
  • The treatment is for my own use
  • I will read the patient information leaflet supplied with inhaler
  • I agree to the terms and conditions

The order process

Answer short medical questionnaire

Choose treatment, register, and pay

Doctor issues prescription online

Medicine posted direct from pharmacy


Customer reviews

“Great service. Ordered my goods and received them very quickly with no problems at all. Will definitely use your services again and I will be recommending yourselves to many people.”17 July 2017 – Keely D., Luton

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“1st time I have ever ordered on line and was very happy with the service and how quick and easy it was to do”21 December 2016 – Bezza K., Kent

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