Omeprazole suppresses the symptoms of acid reflux for around 24 hours. Available to buy online from Dr Fox.

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Buy Omeprazole online

  1. Read medical information about acid reflux treatment
  2. Answer medical questions to check for eligibility
  3. Reviewed by doctors - posted from UK pharmacy


Omeprazole 10mg (generic)28 capsules£7.95
Omeprazole 10mg (generic)56 capsules£11.95
Losec (Omeprazole) 10mg28 capsules£14.50
Losec (Omeprazole) 10mg56 capsules£23.10

Price match guaranteePrice match guarantee
Prescription issued online - small prescription fee per order.

Prescription fees

Dr Fox supplies medicine on prescription and charges a small prescription fee based on the order value of each prescription.

Prescriptions are issued by our doctors online and sent electronically to our pharmacy.

If you have your own private paper prescription please post to our pharmacy (details).

Dr Fox prices are 25%–50% lower than other UK online clinics.

Order valuePrescription fee
up to £10£1.00
up to £20£2.00
up to £40£3.00
over £40£4.00

Delivery charges

UK delivery only: £2.90 per consultation via Royal Mail 24 Signed For (1-3 working days with tracking).

Parcel forwarding services are not permitted. Use only UK home or work delivery address.

Returns and refunds - unwanted items can be returned within 14 working days for a full refund.

About Omeprazole

Omeprazole is a type of medicine called a proton pump inhibitor (PPI). PPIs have been in use for more than 25 years, and have been shown to be safe and effective treatments for acid reflux/heartburn, and a range of other gastric and duodenal conditions.

In a 2017 review, the authors concluded that all currently available PPIs are effective, and there are only small pharmacological differences in their use.

Pack photo of omeprazole 10mg capsules

Generic Omeprazole

Losec is a brand name for a medicine called omeprazole, the active ingredient.

Lower cost generic Omeprazole 10mg is also available. Generic medicines work in the same way and contain the same quantity of the active ingredient but are usually lower cost than brand-name medicines.

How does Omeprazole relieve acid reflux/indigestion?

The cells which line your stomach, produce acid, using a specific biochemical process known as a 'proton pump'. Omeprazole stops the biological action of these pumps - and hence it is called a 'proton pump inhibitor' (PPI). Symptoms such as acid reflux and heartburn are reduced, because the stomach contents have lowered acidity.

Omeprazole is also effective, when combined with antibiotics, in treating H. Pylori. This is a bacterium sometimes found in the stomach, and associated with the development of gastritis, gastric and duodenal ulcers, and gastric cancer.

How to take Omeprazole

  • Take one 10mg capsule twice a day.
  • Initially, one capsule in the morning, an hour before food if possible.
  • Swallow capsules whole, with a glass of water. They should not be chewed or crushed.
  • If you have trouble swallowing, open the capsule and stir the contents into a small glass of non-carbonated water, or fruit juice. Then drink the entire contents of the glass within 30 minutes.

Who might be suitable for Omeprazole?

Omeprazole is licensed to treat adults, aged over 18, with:

  • Duodenal and gastric ulcers, treatment and prevention
  • H. Pylori infection
  • Reflux esophagitis, treatment and prevention - commonly known as acid reflux/heartburn
  • Gastro-esophaeal reflux disease (GORD)
  • Zollinger Ellison Syndrome

How soon is Omeprazole effective?

It may take 1-2 days to notice an effect from Omeprazole. For best results follow the instructions carefully on how to take it - see above or read the patient leaflet supplied in packs.

Who is not suitable for Omeprazole?

During treatment with Omeprazole, if symptoms develop such as unintended weight loss, vomiting, blood in the vomit, or dark, tarry stools, you must seek urgent medical attention.

Omeprazole should not be taken with Atazanavir, an anti-HIV drug.

Potential side effects of Omeprazole

Most common side effects (1 in 10 users)

  • Headache
  • Abdominal pain
  • Constipation
  • Diarrhoea
  • Flatulence
  • Nausea/vomiting

Uncommon side effects (1 in 100 users)

  • Difficulty sleeping
  • Dizziness
  • Pins and needles
  • Vertigo
  • Abnormal liver function tests
  • Skin rashes
  • Swelling

Rare side effects (1 in 1,000 users)

  • Low red/white cell count
  • Low sodium levels
  • Agitation
  • Confusion
  • Depression
  • Blurred vision
  • Dry mouth
  • Gastrointestinal candidiasis
  • Alopecia
  • Photosensitivity
  • Kidney disease
  • Sweating

Very rare side effects (1 in 10,000 users)

  • Abnormal white cells/red cells (agranulocytosis, pancytopenia)
  • Hallucinations
  • Liver failure
  • Severe skin disease
  • Enlarged breasts in men

Are there any drugs which might interact with Omeprazole?

Omeprazole may lead to a decrease or an increase in the levels of certain drugs in your blood stream.

Omeprazole may lead to a decrease in certain drug levels in your blood stream:

  • Nelfinavir and Atazanavir anti-HIV drugs
  • Clopidogrel - antiplatelet drug
  • Posaconazole, Erlotinib, Ketoconazole, and Itraconazole - antifungals

Omeprazole may lead to an increase in certain drug levels in your blood stream:

  • Saquinavir and Ritonavir anti-HIV drugs
  • Tacrolimus - an immunosuppressant drug
  • Methotrexate - a chemotherapy drug

Some drugs may lead to a decrease or an increase of Omeprazole in the blood stream.

Drugs which may decrease omeprazole levels:

  • Rifampicin - an anti-TB drug
  • St John's Wort - a herbal remedy

Drugs which may increase Omeprazole levels:

  • Clarithromycin and Voriconazole - antifungals

Any special warnings/precautions for use?

The following have been reported with long-term use of Omeprazole:

  • Low magnesium levels. Symptoms include fatigue, delirium, convulsions and cardiac arrhythmias. Periodic checks of blood magnesium levels are recommended.
  • Possible increase in the risk of fractures at the hip, wrist and spine, hence patients are recommended to follow national guidelines for prevention and treatment of osteoporosis, and to have an adequate intake of calcium and vitamin D.
  • Reduced absorption of vitamin B12.
  • A rare condition 'subacute cutaneous lupus erythematosis' (SCLE). If you develop a skin rash on sunlight exposed areas, always consult your doctor promptly.
  • As Losec contains lactose, it is not suitable for patients with galactose intolerance.
  • A slightly higher risk of gastroenteritis such as Campylobacter and Salmonella.
  • Possible dizziness, visual disturbances, and muscular weakness - if affected do not drive or operate heavy machinery.

Is Omeprazole safe in pregnancy and/or breastfeeding?

You must discuss this with your doctor as no medication should be taken in pregnancy unless absolutely necessary. However, no adverse effects have been noted, and Omeprazole may be taken in pregnancy and breastfeeding if you are advised to do so.

When would taking Omeprazole become an emergency?

If you have any symptoms or signs suggestive of an acute allergic reaction (anaphylaxis), you must get medical help immediately (telephone 999 if in the UK).

Symptoms/signs of an acute allergic reaction include:

  • Difficulty breathing, tight chest, wheezing
  • Swelling of the face, lips, or tongue
  • Skin rash – urticaria/hives
  • Confusion/collapse/unconsciousness

For more information see NHS - Anaphylaxis.

Patient Information Leaflet

Illustration of patient leaflet from medicine packet

The Patient Information Leaflet (PIL) is the leaflet included in the pack with a medicine and must be read before taking the medicine. It is written for patients and gives information about taking or using a medicine.

Losec Patient Information Leaflet

Dr Tony Steele

Authored 18 January 2019 by Dr Tony Steele
MB ChB Sheffield University 1983. Former hospital doctor and GP.

Reviewed by Dr B. Babor, Dr A. Wood, Dr P. Hunt
Last reviewed 18 January 2019
Last updated 20 October 2020


Product reviews

Omeprazole rated 4.9/5 in 20 product reviews

See over 29,000 service reviews of Dr Fox

Omeprazole 10mg

Working really well

25/01/2021 19:34
Anonymous Verified

Omeprazole 10mg

Perfect, does the job as needed.

25/01/2021 10:56
Anonymous Verified

Omeprazole 10mg

immediate relief

11/01/2021 13:03
Anonymous Verified

Omeprazole 10mg

I use these infrequently for reflux, works well in a short amount of time.

09/01/2021 20:06
Anonymous Verified

Omeprazole 10mg

Good service

07/12/2020 18:02
Anonymous Verified

Read more reviews

The order process

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