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About Mounjaro weight loss injections

Mounjaro is a once-weekly weight loss injection containing the active ingredient tirzepatide. It is prescribed to help eligible adults lose weight alongside healthy eating and regular physical activity.

Mounjaro comes as an easy-to-use pre-filled KwikPen. The injection is given just once a week using a very small needle and most people find it becomes part of their routine quickly.

How do Mounjaro weight loss injections work?

Mounjaro works by mimicking two naturally occurring gut hormones called GIP and GLP-1.

These hormones are released after eating and help regulate appetite, food intake and blood sugar levels. By copying their actions, Mounjaro can help you:

• Feel less hungry
• Feel fuller for longer after meals
• Reduce food cravings
• Eat smaller portions more comfortably
• Lose weight when used alongside healthy lifestyle changes

Many people notice their appetite reducing within the first few weeks of treatment, although weight loss results vary between individuals.

How to use Mounjaro weight loss injections

Mounjaro is injected under the skin once a week, ideally on the same day each week.

The injection can be given into your:

• Stomach (abdomen)
• Thigh
• Upper arm

The pen can be used at any time of day, with or without food.

If you are new to injections, don't worry. The pen is designed to be simple to use and comes with full instructions. Most people become comfortable using it after their first few doses.

We recommend rotating injection sites each week to help avoid irritation.

Mounjaro Dosages

Mounjaro is started at a low dose and increased gradually to help reduce side effects.

Available strengths include[Product boxes displayed here]:

• 2.5mg
• 5mg
• 7.5mg
• 10mg
• 12.5mg
• 15mg

Most people begin with 2.5mg once weekly before increasing gradually according to the recommended dosing schedule and clinical response.

Not everyone needs to reach the highest dose. The most suitable maintenance dose depends on how well the treatment is working and how well it is tolerated.

When not to use Mounjaro weight loss injections

Mounjaro may not be suitable if you:

• Are allergic to tirzepatide or any of the ingredients
• Are pregnant or planning a pregnancy
• Are breastfeeding
• Have been advised by a healthcare professional not to use this medicine

Suitability is assessed through the online consultation before treatment can be prescribed.

Cautions for using Mounjaro weight loss injections

Tell your clinician before using Mounjaro if you:

• Have kidney problems
• Have liver problems or gallstones
• Have a history of pancreatitis
• Have severe digestive disorders
• Have diabetic eye disease (retinopathy)
• Are taking medicines for diabetes
• Have recently experienced significant dehydration

Additional precautions and warnings are detailed in the Patient Information Leaflet.

Mounjaro weight loss injections and other medicines

Tell your clinician about all medicines you are taking, including prescription medicines, over-the-counter medicines and herbal products.

Particular care may be needed if you use:

• Insulin
• Sulfonylurea medicines for diabetes
• Medicines that require careful monitoring of blood glucose
• Medicines where delayed stomach emptying may affect absorption
• Oral contraceptive pills*

*Mounjaro may reduce the effectiveness of oral contraceptive pills during initiation and dose escalation. Additional contraception may be required.

Possible side effects of Mounjaro weight loss injections

Common side effects may affect up to 1 in 10 people and include:

• Nausea
• Vomiting
• Diarrhoea
• Constipation
• Abdominal pain
• Indigestion
• Reduced appetite
• Headache
• Fatigue

These side effects are often most noticeable when starting treatment or after a dose increase and usually improve over time.

Serious side effects

Seek urgent medical attention if you experience:

• Severe or persistent abdominal pain
• Signs of pancreatitis
• Severe allergic reactions
• Severe dehydration due to vomiting or diarrhoea

For complete information, read the Patient Information Leaflet supplied with your medication.

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