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How does Foundayo work?

Foundayo contains orforglipron, which acts on GLP-1 receptors in the body, which reduces appetite and food intake.

Foundayo can:

• Reduce hunger and appetite
• Increase feelings of fullness
• Help you eat less
• Support weight loss and long-term weight management.

Foundayo should be used alongside changes to diet and physical activity.

Weight-loss results vary from person to person and are influenced by factors including how long treatment is continued and changes to diet and physical activity.

How to take Foundayo

Take one Foundayo tablet once daily.

Foundayo can be taken:

• At any time of day
• With or without food
• Without any restrictions on how much water you drink with it.

Swallow the tablet whole. Do not break, crush or chew it.

Do not take more than one Foundayo tablet in a day.

Foundayo dosages

Foundayo is available in 6 strengths:

• 0.8mg
• 2.5mg
• 5.5mg
• 9mg
• 14.5mg
• 17.2mg

Treatment usually starts with 0.8mg once daily for 30 days, followed by 2.5mg once daily.

After at least 30 days at each dose, the dose can be increased if needed and if side effects are manageable.

0.8mg ↔ 2.5mg ↔ 5.5mg ↔ 9mg ↔ 14.5mg ↔ 17.2mg

Do not take more than one tablet to make up a higher dose.

When not to use Foundayo

Do not take Foundayo if you:

• Are allergic to orforglipron or any of the other ingredients
• Are pregnant or planning to become pregnant
• Are breastfeeding.

It is not licensed for children or young people under 18 years of age.

Cautions for using Foundayo

Tell your clinician before starting Foundayo if you:

• Have a history of pancreatitis
• Have severe digestive problems
• Have liver problems or gallstones
• Have kidney problems
• Have diabetic eye disease

Foundayo and other medicines

Tell your clinician about all medicines, supplements and herbal remedies you take before starting Foundayo.

These medicines may interact with Foundayo:

• Antibiotics, including clarithromycin and rifampicin
• Antifungal medicines, including itraconazole and ketoconazole
• Medicines for epilepsy, including carbamazepine and phenytoin
• Antiviral medicines
• Medicines used to treat pulmonary hypertension
• Herbal medicines containing St John's wort.
• Insulin and sulfonylurea medicines for diabetes
• Medicines that require careful monitoring of blood glucose
• Simvastatin and rosuvastatin for high cholesterol
• Some anaesthetics or sedatives.

Always tell other doctors and healthcare professionals that you are taking Foundayo, particularly if you are due to have an operation or procedure requiring anaesthesia or sedation.

Foundayo and the contraceptive pill

Foundayo may reduce the effectiveness of oral hormonal contraceptives. If you take a contraceptive pill, use condoms, for 30 days after starting Foundayo and for 30 days after every increase in dose. Alternatively, you could change to a different method of contraception such as the implant or hormonal coil.

Possible side effects of Foundayo

Foundayo can cause nausea, vomiting and diarrhoea,or constipation and stomach pain, particularly when starting treatment or increasing the dose. It is important to drink enough fluids, particularly if you have vomiting or diarrhoea, to reduce the risk of dehydration. Eating smaller meals, and avoiding large or fatty meals may also help.

Other possible side effects include bloating, burping, acid reflux, wind, headache, dizziness, tiredness, hair loss, gallstones, low blood pressure and an increased heart rate.

Seek urgent medical attention if you develop severe and persistent abdominal pain, particularly if it spreads to your back, as this could be due to inflammation of the pancreas.

You should also seek medical advice urgently for symptoms of a serious allergic reaction, sudden changes in your vision or severe dehydration.

For complete information, read the Patient Information Leaflet supplied with your medication.

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