Scopoderm & Kwells interacting medicines

Potential interactions with other medicines

People taking medicines from the following list should consult with their regular doctor before taking Kwells or using Scopoderm patches.

These interactions may not always be important. It is best to check with your own doctor.

Possible increased drowsiness

There may be an increased risk of drowsiness if Scopoderm patches or Kwells are used with medicine from the following list:

  • antipsychotic medicines, eg chlorpromazine
  • barbiturates, e.g. phenobarbital
  • benzodiazepines, e.g. diazepam, temazepam
  • sedating antihistamines, e.g. chlorphenamine, brompheniramine, hydroxyzine
  • sleeping tablets, e.g. zopiclone
  • strong opioid painkillers, e.g. morphine, codeine, dihydrocodeine
  • tricyclic antidepressants, e.g. amitriptyline, doxepin

Possible increase in other side effects

There may be an increased risk of side effects, such as dry mouth, blurred vision or difficulty passing urine, if Scopoderm patches or Kwells are used in combination with other medicines, such as the following:

  • amantadine
  • antiarrhythmic medicines for irregular heartbeats, e.g. disopyramide, propafenone, quinidine
  • antihistamines, eg promethazine, brompheniramine, chlorphenamine, diphenhydramine, triprolidine (some of these are often found in over-the-counter cough and cold remedies)
  • antimuscarinic medicines for Parkinson's symptoms, e.g. procyclidine, orphenadrine, trihexiphenidyl
  • antimuscarinic medicines for urinary incontinence, e.g. oxybutynin, trospium, tolterodine, darifenacin, solifenacin
  • antimuscarinic inhalers for COPD, e.g. aclidinium (Duaklir, Brimica), tiotropium (Spiriva), umeclidinium (Incruse Ellipta, Anoro Ellipta)
  • antipsychotics, e.g. chlorpromazine, clozapine, thioridazine
  • antisickness medicines, e.g. meclozine, cyclizine, prochlorperazine, domperidone, metoclopramide
  • antispasmodics, e.g. atropine, propantheline, hyoscine butylbromide
  • MAOI antidepressants, e.g. phenelzine
  • muscle relaxants, e.g. baclofen, pridinol
  • tricyclic antidepressants, e.g. amitriptyline, clomipramine.

If you experience a dry mouth as a side effect of this medicine you may find that medicines that are designed to dissolve and be absorbed from the tongue, e.g. Maxalt melts for migraine, do not dissolve properly in a dry mouth. To resolve this, drink a mouthful of water before taking oral melt tablets.

If taken with other 'anticholinergic' drugs there is a possible increase in the risk of side effects, especially dry mouth.

See patient leaflets included in medicine boxes, and product information pages (Scopoderm, Kwells), for more details.

Links back to travel sickness

Dr Tony Steele

Authored 22 February 2010 by Dr Tony Steele
MB ChB Sheffield University 1983. Former hospital doctor and GP. GMC no. 2825328

Reviewed by Dr A. Wood, Dr C. Pugh, Dr B. Babor
Last reviewed 04 August 2023
Last updated 19 July 2024
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