Ciprofloxacin Interactions
Ciprofloxacin antibiotic has potential interactions with several other medications.
- Artemether with Lumefantrine
Avoidance of quinolones advised by manufacturer of artemether/lumefantrine - Ciclosporin
Increased risk of nephrotoxicity when quinolones given with ciclosporin - NSAIDs
Possible increased risk of convulsions when quinolones given with NSAIDs - Strontium Ranelate
absorption of quinolones reduced by strontium ranelate (manufacturer of strontium ranelate advises avoid concomitant use) - Theophylline
Possible increased risk of convulsions when quinolones given with theophylline - Zolmitriptan
quinolones possibly inhibit metabolism of zolmitriptan (reduce dose of zolmitriptan) - Antacids
absorption of ciprofloxacin reduced by antacids - Calcium Salts
absorption of ciprofloxacin reduced by calcium salts - Clozapine
ciprofloxacin increases plasma concentration of clozapine - Coumarins Warfarin
ciprofloxacin enhances anticoagulant effect of coumarins - Duloxetine
Ciprofloxacin inhibits metabolism of duloxetine – vavoid concomitant use - Glibenclamide
ciprofloxacin possibly enhances effects of glibenclamide
- Iron
absorption of ciprofloxacin reduced by oral iron - Methotrexate
ciprofloxacin possibly reduces excretion of methotrexate (increased risk of toxicity) - Olanzapine
ciprofloxacin possibly increases plasma concentration of olanzapine - Opioid Analgesics
manufacturer of ciprofloxacin advises avoid premedication with opioid analgesics (reduced plasma concentration of ciprofloxacin) when ciprofloxacin used for surgical prophylaxis - Phenytoin
ciprofloxacin increases or decreases plasma concentration of phenytoin - Probenecid
excretion of ciprofloxacin reduced by probenecid (increased plasma concentration) - Ropinirole
ciprofloxacin inhibits metabolism of ropinirole (increased plasma concentration) - Sevelamer
bioavailability of ciprofloxacin reduced by sevelamer - Sucralfate
absorption of ciprofloxacin reduced by sucralfate - Theophylline
Ciprofloxacin increases plasma concentration of theophylline - Tizanidine
Ciprofloxacin increases plasma concentration of tizanidine (increased risk of toxicity) – avoid concomitant use - Zinc
absorption of ciprofloxacin reduced by zinc
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